Publications of ChelSMA in scientific periodicals

29. Kalmykova A.V., Mironova T.F., Mironov V.A.

Variability of a sinoatrial rate of heart at a bronchial asthma

State educational institution of higher education of the Federal Agency for Healthcare and Social Development «Chelyabinsk State Medical Akademy», Chelyabinsk, Russia.

Клиническая медицина/”Klinicheskaia Meditsina”, 2007, №6, c. 28-36

 

30. Karpova M.I., Shamurov J.S., Markova V.V.

The level of IL-1 and TNF-α at patients with the primary headaches

State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia

At patients with a migraine and a tension-type headache the content of IL-1, IL-1β, TNF- in peripheral blood serum was studied. At a tension-type headache and at a migraine significantly higher levels of IL-1  and TNF- were revealed. The comparative analysis of IL-1 , IL-1β, TNF- at a various clinical course of cephalalgias showed that patients with episodic tension-type headache concentration of these cytokines did not differ from that of a healthy group. In chronic tension-type headaches throughout the levels IL-1α and TNF-α  were higher than episodic. In patients with migraine had increased concentrations of IL-1α, TNF-α irrespective of the clinical course. If tension-type headaches found positive correlation between the frequency of painful days, with the level of IL-1α and TNF-α, with a migraine - the content of TNF-α.

Российский иммунологический журнал/“Russian Journal of Immunology”, 2011 т. 4 (15), №1, c.50-55

 

31. Kazachkov E.L., Kazimirova A.A.

Role of matrix metalloproteinases and their tissues inhibitor in morphogenesis of chronic gastritis helicobacter pylori associated in children

State educational institution of higher education of the federal Agency for Healthcare and Social Development "Chelyabinsk State Medical Academy", Chelyabinsk, Russia

Gastrobiopsies of 40 children in age of from 7 till 15 tears are studied. There are 30 children with clinical diagnosis – chronical gastritis Helicobacter pylori associated and 10 children with functial dyspepsia. The level of MMP-2, MMP-9 and TIMP-1 in mucous membrane of stomach in fundus and antrium in Helicobacter pylori associated chronical gastritis goes higher, then the same data in functial dyspepsia. It is shown, that increase of exhibiting of labels of markers MMP-9, MMP-2 is the most expressed in fundus of mucous membrane of stomach and correlates with a degree of activity of an inflammation. Significant increase of level of TIMP-1 testifeis to a compensational effort of functios and can serve as the reason of remolding of mucous membrain of stomach  with increase of collagenoformationю Increas of synthesis and activation MMP-9 and MMP-2 stimulate reactivation of ulcerous properties these metalloproteinases. The received results helped to reveal teratogenic medicamental influens on pathogenesis of  Helicobacter pylori associated gastritis.

Архив патологии/"Arkhiv Patologii", 2009, том 71, №2, с. 64-65

 

32. Kazachkov E.L., Voropaeva E.E., Kovalenko V.L., Kazachkova E.A.

Morphofunktional characteristic of the endometrium at womans with syndrome of the loss pregnancy on the early periods infectious-inflammatory genesis

State educational institution of higher education of the federal Agency for Healthcare and Social Development "Chelyabinsk State Medical Academy", Chelyabinsk, Russia

The perfomed examination of 82 patients reproductive age, sufferring loss pregnancy of the early periods infectious-inflammatory genesis. I group has formed 56 womans, having one spontaneous abortion, II group - 26 patients with two and more spontaneous miscarriage in anamnesis. In work is used complex of the methods of the diagnostics genital infection, gistologic, gistochemical, statistical methods of the study. It is installed that patients of II groups more often have infectious-inflammatory diseases sexual organ. Beside womans of both groups in 100% events is registered chronic endometritis, mainly, ureaplasmic-mycoplasmic and viral, but in 57% - mixed etiology. Herewith beside patients of II groups realistically more denominated phenomenas fibrosis and atrophies of stroma of endometrium, damage reception device, oppression tissues protective immune reaction.

Архив патологии/"Arkhiv Patologii", 2010, том 72, №1, с. 23-26

 

 33. Kolesnikov O.L., Dolgushin I.I., Selyanina G.A., Shadrina I.V., Shalashova M.A., Kolesnikova A.A.

The influence of the level of reactive anxiety on the state of immune system and metabolism

State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia

In the study of reactive anxiety, the state of immune system and metabolism in healthy people it was found that the indices of temperament, health, level of leukocytes, platelets, glucose, albumin and fibrinogen in the persons with low, moderate and high levels of reactive anxiety different significantly.

Бюллетень экспериментальной биологии и медицины/”Bulletin of Experimental Biology and Medicine”, 2006, том 142, №8, с. 185-187

 

34. Kolupaev V.A., Sashenkov S.L., Dolgushin I.I.

Effects of anaerobic and aerobic exercises in athletes on the variation of the parameters of oxygen transport systems in different seasons of the year

Ural State University of Physical Culture, Chelyabinsk, Russia

State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia

Observations of the changes in the functional states of athletes of two specializations (wrestlers and skiers) carried out for four years are summarized. The effects of seasonal changes superimposed on adaptive changes caused by training are analyzed. Changes in the erythron reflecting the modulating effect of seasonal environmental changes on the state of the blood system have been found.

Физиология человека/”Human Physiology”, 2008, том 34, №2, с. 139-142

35. Korobeinikova E.N., Kudrevich Yu.V., Yashina L.M.

Oxidative serum protein modification in patients with coronary heart disease and essential hypertension with and without dyslipoproteinemia

State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia

Level of products of oxidative modification of proteins has been investigated both in sick and in healthy people. It has been found that these products actually increase in sick persons: in the patients with coronary disease and in the patients with lipid metabolism disturbances. It has been concluded to apply this method for examination of patients.

Kлиническая лабораторная диагностика/”Klinicheskaia Laboratornaia Diagnostika”, 2006, №4, с. 22-24

 

36. Kovalenko V.L., Kazachkov E.L., Kazimirova А.A.

Significance of some growth factors in pathogenesis of children's chronic gastritis

State educational institution of higher education of the federal Agency for Healthcare and Social Development "Chelyabinsk State Medical Academy", Chelyabinsk, Russia

The gastrobioptats of 44 children in the age of from 7 till 15 years with the clinical diagnosis chronic gastritis (CG) were investigated. At Нр-associated CG (24 patients) the acceleration of processes of cellular renewal in a mucous membrane of antral and fundal departments of a stomach in comparison with the intensity proliferation and apoptosis at Hp-associated CG (20 children) are marked. It is shown, that amplification of proliferation of a mucous membrane of stomach elements (MMS) is connected with a high density of EGFR especially at Hp-associated CG, that is observed usually at insufficient level of TGFR- β.  The important role and multidirectional functional loading of  EGFR and TGFR-β  in pathogenesis of CG were established. For this disease the maximal expressiveness of expression of EGFR, directly correlating with a level of processes of cellular updating and a degree of activity of inflammatory process is characterized. Thus the intensification of proliferation and apoptosis is connected, on the one hand, with the increasing of expression of EGFR on the other – with the insufficient level of representation of TGFR-β on cell membranes of MMS that is especially expressed at children with Hp-associated CG.

Архив патологии/"Arkhiv Patologii", 2008, том 70, №2, с. 3-5

 

37. Kovalenko V.L., Kazachkov E.L., Voropaeva E.E., Kazachkova E.A.

Morphofunctional characteristic of epithelium and extracellular matrix of endometrium at without child-bearing pregnancy of the early periods associated with chronic endometritis

State educational institution of higher education of the federal Agency for Healthcare and Social Development "Chelyabinsk State Medical Academy", Chelyabinsk, Russia

At without child-bearing pregnancy, associated with chronic endometritis, in mucous of the uteris is installed reduction to expressions TGFR-β, gelatinases and increasing level of expression TIMP-1 and EGFR that confirms pathogenetic relationship between disbalance of factor growing, endoproteases their inhibitor, indicates to active participation these cytokines and endopeptidases in inflammatory, reparative process and remodeling of tissues. Presented disbalance of grow factor , proteases and antiproteases, probably, serves the reason remodeling mucous of the uteris with progression of collagengenesis and atrophies of the glandular apparatus on background persistence exciter that can be one of the factor of the development to loss of pregnancy. This dictates need of the undertaking elimination exciter infectious-inflammatory process in endometrium in most early periods from begin diseases and allows to mark the approaches to target medicamentic influence on some pathogenetic links of disease.

Архив патологии/"Arkhiv Patologii", 2010, том 72, №5, с. 40-43

 

38. Kovalenko V.L., Koksharov V.N.

Frequency of divergence of final clinical and anatomical diagnosis as indicator of quality of rendering medical aid

State educational institution of higher education of the federal Agency for Healthcare and Social Development «Chelyabinsk State Medical Academy», Chelyabinsk, Russia

Chelyabinsk Regional Bureau of Pathology, Chelyabinsk, Russia

Necessity in updating of parameter of divergence frequency of the final clinical and anatomical diagnosis, as indicator of quality of rendering medical aid was been shown. This parameter should be used as the integral index and based on leading analysis principles of the detected defect of rendering medical aid, as controllability registration of basic disease when the patient resorts for the medical aid at the first time, as the stage of rendering medical aid in which defect of diagnostics and treatment was made.

Архив патологии/"Arkhiv Patologii", 2007, том 69, №1, с. 13-16

 

39. Kovalenko V.L., Pasternak I.A., Kulaev I.A., Pasternak A.E.

The morphological particularities of the thyroid gland at the children's population, living in unfavourable ecological condition

State educational institution of higher education of the federal Agency for Healthcare and Social Development "Chelyabinsk State Medical Academy", Chelyabinsk, Russia

There have been made clinical and anatomic comparisons between deadborns and children till 18 years old died of causes not connected with endocrine pathology (n=179) has been accomplished. Moreover, results of research of operative material from children lived at the Southern Urals who had been operated to thyroid pathology (n=516) has been analyzed.

Вестник РАМН/"Vestnik Rossiǐskoǐ Akademii Meditsinskikh Nauk", 2010, №6, с. 30-34

40. Kovalenko V.L., Voropaeva E.E., Kazachkov E.L., Kazachkova E.A.

Pathomorphology endometry at bacterial vaginosis associated with chronic endometritis

State educational institution of higher education of the federal Agency for Healthcare and Social Development "Chelyabinsk State Medical Academy", Chelyabinsk, Russia

The results of complex morphologic and morphometric examination of bioptats of endometry of 133 female patients who have verificed bacterial vaginosis (BV) are performed in this research. It,s found that 100% of those patients who have BV have chronic endometrities (CE). Morphological components of CE at BV are significant distrophyc changes of integmentary epitheliocytes and gland cells, polymorphocellular infiltration of endometrium with cases of tissue limphopenia expressed in different ways, also fibroblastic change of stroma and vessels with lowering of volumentric density of integmentery epithelium of endometry, relative gland volume and increasing of relative volume of conjunctive tissue level. Characteristic structural changes of CE at BV are intensive process of apoptosis of endometrium against a background of its weak proliferative activity which leads to progressive atrophy of endometry and can lead to undeveloping pregnancy. In this case discrinism in endometrium appears in deficiency of progesterone reception of target-cells in endometrium, which leads to disfunction of uterin glands and may cause forming of fetus depletion syndrome.

Архив патологии/"Arkhiv Patologii", 2008, том 70, №2, с. 6-8

 

41. Krupitskaya L.I., Tseilikman V.E., Popova A.S., Sinitsky A.I., Goloshapova T.N., Dubrovskaya V.P., Guzema I.M.

Xanthine oxidase as an indicator of neonatal adaptation

State educational  institution of higher education of the federal Agency for Healthcare and Social Development "Chelyabinsk State Medical Academy", Chelyabinsk, Russia

City Clinical Hospital № 6, Chelyabinsk, Russia

The reactions reflecting adaptation may assume pathological traits under certain conditions. It is necessary to have reliable predictors that characterize adaptive  processes. As this criterion, it is expedient to use the most important marker of free radical oxidation, such as xanthine oxidase (XO) activity. On the basis of the authors` findings, it can be said that it is advisable to apply this test to the screening of the course of adaptation within the first day after birth and to the detection of neonatal who require more scrupulous attention.

Клиническая лабораторная диагностика/"Klinicheskaia Laboratornaia Diagnostika", 2008, №12, c. 16-17

 

42. Krupitskaya L.I., Tseilikman V.E., Popova A.S., Sinitskii A.I., Gornostaeva A.B.

Influence of postnatal hypoxia on Wistar and August rats

State educational  institution of higher education of the federal Agency for Healthcare and Social Development "Chelyabinsk State Medical Academy", Chelyabinsk, Russia

City Clinical Hospital № 6, Chelyabinsk, Russia

It was proved that a hypoxia tolerance often goes with forming of an oxidative stress tolerance and has a genetic predetermination on hypoxic influence. Interline difference of hypoxia sensitivity is mainly defined by difference of oxygen-transport systems state. Genetically predetermined differences between investigated lines gives the August rats the ability to use mechanisms of resistant strategy more effective, and Vistar rats – to use tolerant strategy more effective.

Российский физиологический журнал им. И. Сеченова/"Russian Journal of Physiology", 2009, том 95, №7, c. 773-778

 

43. Kurenkov E.L., Kuznetsov M.E., Rassokhin A.G., ZakharovYu.M.

The content of ribonucleoproteids in the bone marrow erythroblastic islands in various functional states of erythropoiesis

South-Ural Scientific Centre of the Russian Acad. Med. Sci., Chelyabinsk, Russia

Erythroblastic islands of the bone marrow are morphofuctional units of erythropoiesis. The functional state of the erythroblastic islands' erythrokariocytes and central macrophages of the bone marrow was first studied by estimation of the content of ribonucleoproteids in its cells (Brashe reaction). Acute blood loss and posttransfusion polycytemia lead to enhancement of the content of ribonucleoproteids in erythrokariocytes and central macrophages of the bone marrow of the rates.

Росcийский физиологический журнал им. И. М. Сеченова /”Russian Physiological Journal”, 2006,  том 92, №11, с. 1339—1344

Up